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1

âOld Drugs, New Tricksâ â Local controlled drug release systems for treatment of degenerative joint disease

Tryfonidou, Marianna A., de Vries, Geert, Hennink, Wim E., Creemers, Laura B.

Journal:

Advanced Drug Delivery Reviews

Year:

2020

File:

PDF, 1.98 MB

2020

2

Effect of Autologous Bone Marrow Stromal Cell Seeding and Bone Morphogenetic Protein-2 Delivery on Ectopic Bone Formation in a Microsphere/Poly(Propylene Fumarate) Composite

Kempen, Diederik H.R., Kruyt, Moyo C., Lu, Lichun, Wilson, Clayton E., Florschutz, Anthony V., Creemers, Laura B., Yaszemski, Michael J., Dhert, Wouter J.A.

Journal:

Tissue Engineering Part A

Year:

2009

Language:

english

File:

PDF, 10.32 MB

english, 2009

3

Joint injury and osteoarthritis: soluble mediators in the course and treatment of cartilage pathology

Rutgers, Marijn, Saris, Daniël BF, Auw Yang, Kiem Gie, Dhert, Wouter JA, Creemers, Laura B

Journal:

Year:

2009

Language:

english

File:

PDF, 1.06 MB

english, 2009

4

Inflammatory profiles in canine intervertebral disc degeneration

Willems, Nicole, Tellegen, Anna R., Bergknut, Niklas, Creemers, Laura B., Wolfswinkel, Jeannette, Freudigmann, Christian, Benz, Karin, Grinwis, Guy C. M., Tryfonidou, Marianna A., Meij, Björn P.

Journal:

BMC Veterinary Research

Year:

2016

Language:

english

File:

PDF, 1.67 MB

english, 2016

5

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

Cai, Yunpeng, López-Ruiz, Elena, Wengel, Jesper, Creemers, Laura B., Howard, Kenneth A.

Journal:

Journal of Controlled Release

Year:

2017

Language:

english

File:

PDF, 763 KB

english, 2017

6

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, João Pedro, Stein, Jeroen, Cai, Yunpeng, Riemers, Frank, Wexselblatt, Ezequiel, Wengel, Jesper, Tryfonidou, Marianna, Yayon, Avner, Howard, Kenneth A., Creemers, Laura B.

Journal:

Journal of Controlled Release

Year:

2019

Language:

english

File:

PDF, 3.21 MB

english, 2019

7

Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside

Bach, Frances C., Tellegen, Anna R., Beukers, Martijn, Miranda-Bedate, Alberto, Teunissen, Michelle, de Jong, Willem A.M., de Vries, Stefan A.H., Creemers, Laura B., Benz, Karin, Meij, Björn P., Ito,

Journal:

Year:

2018

Language:

english

File:

PDF, 11.39 MB

english, 2018

8

Intradiscal Injection of a Slow Release Formulation of Celecoxib for the Treatment of Dogs with Low Back Pain

Tellegen, Anna, Beukers, Martijn, Miranda-Bedate, Alberto, Willems, Nicole, De Leeuw, Mike, Van Dijk, Maarten, Creemers, Laura, Tryfonidou, Marianna, Meij, Björn

Journal:

Global Spine Journal

Year:

2016

Language:

english

File:

PDF, 93 KB

english, 2016

9

Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage–synovium coculture

Michiel Beekhuizen, Yvonne M. Bastiaansen-Jenniskens, Wendy Koevoet, Daniel B. F. Saris, Wouter J. A. Dhert, Laura B. Creemers, Gerjo J. V. M. van Osch

Journal:

Arthritis & Rheumatism

Year:

2011

Language:

english

File:

PDF, 628 KB

english, 2011

10

Identification of cell surface–specific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase XII varies with age and degeneration

Karen A. Power, Sibylle Grad, Joost P. H. J. Rutges, Laura B. Creemers, Mattie H. P. van Rijen, Peadar O'Gaora, J. Gerard Wall, Mauro Alini, Abhay Pandit, William M. Gallagher

Journal:

Arthritis & Rheumatism

Year:

2011

Language:

english

File:

PDF, 192 KB

english, 2011

11

Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus

Dirk Jan F. Moojen, Peter A.M. Everts, Rose-Minke Schure, Ed P. Overdevest, André van Zundert, Johannes T.A. Knape, René M. Castelein, Laura B. Creemers, Wouter J.A. Dhert

Journal:

Journal of Orthopaedic Research

Year:

2008

Language:

english

File:

PDF, 176 KB

english, 2008

12

Cartilage damage caused by metal implants applied for the treatment of established localized cartilage defects in a rabbit model

Roel J.H. Custers, Laura B. Creemers, Mattie H.P. van Rijen, Ab J. Verbout, Daniel B.F. Saris, Wouter J.A. Dhert

Journal:

Journal of Orthopaedic Research

Year:

2009

Language:

english

File:

PDF, 301 KB

english, 2009

13

Replacement of the medial tibial plateau by a metallic implant in a goat model

Roel J.H. Custers, Daniel B.F. Saris, Laura B. Creemers, Ab J. Verbout, Mattie H.P. van Rijen, Simon C. Mastbergen, Floris P. Lafeber, Wouter J.A. Dhert

Journal:

Journal of Orthopaedic Research

Year:

2010

Language:

english

File:

PDF, 325 KB

english, 2010

14

Efficient synthesis of (+)-nojirimycin and (+)-1-deoxynojirimycin

Peter B. Anzeveno, Laura J. Creemer

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 263 KB

english, 1990

15

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration

Diederik H.R. Kempen, Lichun Lu, Andras Heijink, Theresa E. Hefferan, Laura B. Creemers, Avudaiappan Maran, Michael J. Yaszemski, Wouter J.A. Dhert

Journal:

Year:

2009

Language:

english

File:

PDF, 1.19 MB

english, 2009

16

An efficient, highly stereoselective synthesis of (+)-castanospermine

Peter B. Anzeveno, Paul T. Angell, Laura J. Creemer, Michael R. Whalon

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 232 KB

english, 1990

17

Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling

Vincent Everts, Erwin van der Zee, Laura Creemers, Wouter Beertsen

Journal:

Journal of Molecular Histology

Year:

1996

Language:

english

File:

PDF, 3.77 MB

english, 1996

18

Correlation of meiotic events in testis sections and microspreads of mouse spermatocytes relative to the mid-pachytene checkpoint

Terry Ashley, Ann P. Gaeth, Laura B. Creemers, Adelle M. Hack, Dirk G. de Rooij

Journal:

Year:

2004

Language:

english

File:

PDF, 444 KB

english, 2004

19

Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering

Diederik H.R. Kempen, Lichun Lu, Teresa E. Hefferan, Laura B. Creemers, Avudaiappan Maran, Kelly L. Classic, Wouter J.A. Dhert, Michael J. Yaszemski

Journal:

Year:

2008

Language:

english

File:

PDF, 1.03 MB

english, 2008

20

Non-invasive screening method for simultaneous evaluation of in vivo growth factor release profiles from multiple ectopic bone tissue engineering implants

Diederik H.R. Kempen, Lichun Lu, Kelly L. Classic, Theresa E. Hefferan, Laura B. Creemers, Avudaiappan Maran, Wouter J.A. Dhert, Michael J. Yaszemski

Journal:

Journal of Controlled Release

Year:

2008

Language:

english

File:

PDF, 630 KB

english, 2008

21

Non-invasive monitoring of BMP-2 retention and bone formation in composites for bone tissue engineering using SPECT/CT and scintillation probes

Diederik H.R. Kempen, Michael J. Yaszemski, Andras Heijink, Theresa E. Hefferan, Laura B. Creemers, Jason Britson, Avudaiappan Maran, Kelly L. Classic, Wouter J.A. Dhert, Lichun Lu

Journal:

Journal of Controlled Release

Year:

2009

Language:

english

File:

PDF, 500 KB

english, 2009

22

Involvement of V-ATPases in the Digestion of Soft Connective Tissue Collagen

Laura B. Creemers, Ineke D.C. Jansen, Kees A. Hoeben, Wouter Beertsen, Vincent Everts

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 1.05 MB

english, 1998

23

Spermatogonial stem cell transplantation

Fariborz Izadyar, Laura B. Creemers, Federica M.F. van Dissel-Emiliani, Ans M.M. van Pelt, Dirk G. de Rooij

Journal:

Molecular and Cellular Endocrinology

Year:

2000

Language:

english

File:

PDF, 99 KB

english, 2000

24

Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue

Laura B. Creemers, Ineke D.C. Jansen, Andrew J.P. Docherty, John J. Reynolds, Wouter Beertsen, Vincent Everts

Journal:

Year:

1998

Language:

english

File:

PDF, 1.04 MB

english, 1998

25

Effect of Collagen Type I or Type II on Chondrogenesis by Cultured Human Articular Chondrocytes

Rutgers, Marijn, Saris, Daniel B., Vonk, Lucienne A., van Rijen, Mattie H., Akrum, Vanessa, Langeveld, Danielle, van Boxtel, Antonette, Dhert, Wouter J., Creemers, Laura B.

Journal:

Tissue Engineering Part A

Year:

2013

Language:

english

File:

PDF, 288 KB

english, 2013

26

Development of a Cryopreservation Protocol for Type A Spermatogonia

FARIBORZ IZADYAR, J. J. MATTHIJS-RIJSENBILT, KRISTA DEN OUDEN, LAURA B. CREEMERS, HENRI WOELDERS, DIRK G. de ROOIJ

Journal:

Journal of Andrology

Year:

2002

Language:

english

File:

PDF, 234 KB

english, 2002

27

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in anin vitroregeneration model

Tsuchida, Anika I, Beekhuizen, Michiel, Rutgers, Marijn, van Osch, Gerjo JVM, Bekkers, Joris EJ, Bot, Arjan GJ, Geurts, Bernd, Dhert, Wouter JA, Saris, Daniel BF, Creemers, Laura B

Journal:

Arthritis Research & Therapy

Year:

2012

Language:

english

File:

PDF, 469 KB

english, 2012

28

Growth Factor Interactions in Bone Regeneration

Kempen, Diederik H.R., Creemers, Laura B., Alblas, Jacqueline, Lu, Lichun, Verbout, Abraham J., Yaszemski, Michael J., Dhert, Wouter J.A.

Journal:

Tissue Engineering Part B Reviews

Year:

2010

Language:

english

File:

PDF, 378 KB

english, 2010

29

A facile, practical synthesis of 2,6-dideoxy-2,6-imino-7-O-.beta.-D-glucopyranosyl-D-glycero-L-gulo-heptitol (MDL 25,637)

Anzeveno, Peter B., Creemer, Laura J., Daniel, John K., King, Chi Hsin R., Liu, Paul S.

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 561 KB

english, 1989

30

Modulating Endochondral Ossification of Multipotent Stromal Cells for Bone Regeneration

Gawlitta, Debby, Farrell, Eric, Malda, Jos, Creemers, Laura B., Alblas, Jacqueline, Dhert, Wouter J.A.

Journal:

Tissue Engineering Part B Reviews

Year:

2010

Language:

english

File:

PDF, 283 KB

english, 2010

31

The Effect of Timing of Mechanical Stimulation on Proliferation and Differentiation of Goat Bone Marrow Stem Cells Cultured on Braided PLGA Scaffolds

van Eijk, Floor, Saris, Daniel B.F., Creemers, Laura B., Riesle, Jens, Willems, W. Jaap, van Blitterswijk, Clemens A., Verbout, Abraham J., Dhert, Wouter J.A.

Journal:

Tissue Engineering Part A

Year:

2008

Language:

english

File:

PDF, 467 KB

english, 2008

32

Chondrogenic Potential of Articular Chondrocytes Depends on Their Original Location

Bekkers, Joris E.J., Saris, Daniel B.F., Tsuchida, Anika Iris, van Rijen, Mattie H.P., Dhert, Wouter J.A., Creemers, Laura B.

Journal:

Tissue Engineering Part A

Year:

2013

Language:

english

File:

PDF, 788 KB

english, 2013

33

Effect of Transforming Growth Factor-Beta and Growth Differentiation Factor-5 on Proliferation and Matrix Production by Human Bone Marrow Stromal Cells Cultured on Braided Poly Lactic-Co-Glycolic Acid Scaffolds for Ligament Tissue Engineering

Jenner, J.M.G.Th., van Eijk, F., Saris, D.B.F., Willems, W.J., Dhert, W.J.A., Creemers, Laura B.

Journal:

Tissue Engineering

Year:

2007

Language:

english

File:

PDF, 7.12 MB

english, 2007

34

Osteoarthritis treatment using autologous conditioned serum after placebo

Rutgers, Marijn, Creemers, Laura B, Yang, Kiem Gie Auw, Raijmakers, Natasja J H, Dhert, Wouter J A, Saris, Daniel B F

Journal:

Acta Orthopaedica

Year:

2015

Language:

english

File:

PDF, 481 KB

english, 2015

35

Pronounced biomaterial dependency in cartilage regeneration using nonexpanded compared with expanded chondrocytes

Tsuchida, Anika I, Bekkers, Joris EJ, Beekhuizen, Michiel, Vonk, Lucienne A, Dhert, Wouter JA, Saris, Daniël BF, Creemers, Laura B

Journal:

Regenerative Medicine

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

36

Enhanced Bone Morphogenetic Protein-2-Induced Ectopic and Orthotopic Bone Formation by Intermittent Parathyroid Hormone (1–34) Administration

Kempen, Diederik H.R., Lu, Lichun, Hefferan, Theresa E., Creemers, Laura B., Heijink, Andras, Maran, Avudaiappan, Dhert, Wouter J.A., Yaszemski, Michael J.

Journal:

Tissue Engineering Part A

Year:

2010

Language:

english

File:

PDF, 1.22 MB

english, 2010

37

Applicability of a Newly Developed Bioassay for Determining Bioactivity of Anti-Inflammatory Compounds in Release Studies −Celecoxib and Triamcinolone Acetonide Released from Novel PLGA-Based Microspheres

Yang, Hsiao-yin, van Dijk, Maarten, Licht, Ruud, Beekhuizen, Michiel, van Rijen, Mattie, Janstål, Martina Källrot, Öner, F. Cumhur, Dhert, Wouter J. A., Schumann, Detlef, Creemers, Laura B.

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 1024 KB

english, 2015

38

Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

Tsuchida, Anika I, Beekhuizen, Michiel, ‘t Hart, Marieke C, Radstake, Timothy, Dhert, Wouter, Saris, Daniel, van Osch, Gerjo, Creemers, Laura B

Journal:

Arthritis Research & Therapy

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

39

In Vivo Matrix Production by Bone Marrow Stromal Cells Seeded on PLGA Scaffolds for Ligament Tissue Engineering

van Eijk, Floor, Saris, Daniel B.F., Fedorovich, Natalja E., Kruyt, Moyo C., Willems, W. Jaap, Verbout, Abraham J., Martens, Anton C., Dhert, Wouter J.A., Creemers, Laura

Journal:

Tissue Engineering Part A

Year:

2009

Language:

english

File:

PDF, 33.06 MB

english, 2009

40

Direct cell-cell contact with chondrocytes is a key mechanism in multipotent mesenchymal stromal cell-mediated chondrogenesis

de Windt, Tommy S, Saris, Daniel B, Slaper-Cortenbach, Ineke C.M., Van Rijen, Mattie H.P., Gawlitta, Debby, Creemers, Laura, de Weger, Roel A, Dhert, Wouter, Vonk, Lucienne A

Journal:

Tissue Engineering Part A

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

41

Mechanisms of Intervertebral Disk Degeneration/Injury and Pain: A Review

Ito, Keita, Creemers, Laura

Journal:

Global Spine Journal

Year:

2013

Language:

english

File:

PDF, 154 KB

english, 2013

42

Establishment of Cell Lines with Rat Spermatogonial Stem Cell Characteristics

van Pelt, Ans M. M., Roepers-Gajadien, Hermien L., Gademan, Iris S., Creemers, Laura B., de Rooij, Dirk G., van Dissel-Emiliani, Federica M. F.

Journal:

Year:

2002

Language:

english

File:

PDF, 332 KB

english, 2002

43

Nerves are more abundant than blood vessels in the degenerate human intervertebral disc

Binch, Abbie L. A., Cole, Ashley A., Breakwell, Lee M., Michael, Antony L. R., Chiverton, Neil, Creemers, Laura B., Cross, Alison K., Le Maitre, Christine L.

Journal:

Arthritis Research & Therapy

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

44

Trends in incidence, treatment and survival of small bowel adenocarcinomas between 1999 and 2013: a population-based study in The Netherlands

Legué, Laura M., Bernards, Nienke, Gerritse, Sophie L., van Oudheusden, Thijs R., de Hingh, Ignace H. J. T., Creemers, Geert-Jan M., ten Tije, Albert J., Lemmens, Valery E. P. P.

Journal:

Acta Oncologica

Year:

2016

Language:

english

File:

PDF, 833 KB

english, 2016

45

Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration

Willems, Nicole, Bach, Frances C, Plomp, Saskia G M, van Rijen, Mattie HP, Wolfswinkel, Jeannette, Grinwis, Guy CM, Bos, Clemens, Strijkers, Gustav J, Dhert, Wouter JA, Meij, Björn P, Creemers, Laura

Journal:

Arthritis Research & Therapy

Year:

2015

Language:

english

File:

PDF, 2.63 MB

english, 2015

46

Increased caveolin-1 in intervertebral disc degeneration facilitates repair

Bach, Frances C., Zhang, Ying, Miranda-Bedate, Alberto, Verdonschot, Lucy C., Bergknut, Niklas, Creemers, Laura B., Ito, Keita, Sakai, Daisuke, Chan, Danny, Meij, Björn P., Tryfonidou, Marianna A.

Journal:

Arthritis Research & Therapy

Year:

2016

Language:

english

File:

PDF, 3.07 MB

english, 2016

47

Osteogenic protein 1 does not stimulate a regenerative effect in cultured human degenerated nucleus pulposus tissue

van Dijk, Bart G. M., Potier, Esther, van Dijk, Maarten, Creemers, Laura B., Ito, Keita

Journal:

Journal of Tissue Engineering and Regenerative Medicine

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

48

No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells Despite Upregulation Extracellular Matrix Genes

Krouwels, Anita, Popov-Celeketic, Jelena, Plomp, Saskia G.M., Dhert, Wouter J.A., Öner, F.Cumhur, Bank, Ruud A., PhD, Laura B. Creemers

Journal:

Year:

2015

Language:

english

File:

PDF, 3.16 MB

english, 2015

49

Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration

Willems, Nicole, Mihov, George, Grinwis, Guy C.M., van Dijk, Maarten, Schumann, Detlef, Bos, Clemens, Strijkers, Gustav J., Dhert, Wouter J.A., Meij, Björn P., Creemers, Laura B., Tryfonidou, Marianna

Journal:

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Year:

2015

Language:

english

File:

PDF, 509 KB

english, 2015

50

Bone morphogenetic protein-2, but not mesenchymal stromal cells, exert regenerative effects on canine and human nucleus pulposus cells

Bach, Frances, Miranda-Bedate, Alberto, van Heel, Ferdi, Riemers, Frank, Muller, Margot, Creemers, Laura, Ito, Keita, Benz, Karin, Meij, Björn, Tryfonidou, M.

Journal:

Tissue Engineering Part A

Year:

2016

Language:

english

File:

PDF, 3.03 MB

english, 2016